DCAF2 is essential for the development of uterine epithelia and mouse fertility
Overall, our findings highlight a previously unrecognized but indispensable role for DCAF2 in the development of uterine luminal and glandular epithelium by orchestrating PGR and estrogen receptor responses. Its deficiency in the uterus leads to mouse infertility.
Authors
- Man Yang (ORCID: https://orcid.org/0000-0001-8432-5707)
- Liang Zhang (ORCID: https://orcid.org/0000-0002-7672-1168)
- Kaixuan Wang (ORCID: https://orcid.org/0000-0001-8091-6083)
- Hongya Zhang
- Cong Zhang (ORCID: https://orcid.org/0000-0002-0952-2441)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shandong Normal University (CN)
- Jinan Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.3389/fcell.2024.1474660
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhejiang University