Causal association of epigenetic age acceleration and risk of subacute thyroiditis: a bidirectional Mendelian randomization study
The bidirectional MR analysis concluded that an increase in PhenoAA was correlated with a higher risk of SAT, indicating a potential causal relationship between PhenoAA and risk of SAT. Conversely, SAT was found to be closely associated with IEAA, suggesting that SAT may accelerate the aging process. Slowing down biological aging has emerged as a new research direction in curbing SAT.
Authors
- Bingbing Shen (ORCID: https://orcid.org/0000-0002-8832-9147)
- Xiaofeng Zheng (ORCID: https://orcid.org/0000-0001-6790-0669)
- Lin Yang (ORCID: https://orcid.org/0000-0002-2767-0026)
- Yang Liu (ORCID: https://orcid.org/0000-0002-8195-7706)
- Zhihui Li (ORCID: https://orcid.org/0000-0003-2447-9645)
- Jiaye Liu (ORCID: https://orcid.org/0000-0003-4434-3120)
- Yusheng Pu
Institutions
- Dalian Medical University (CN)
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s13148-024-01743-6
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- China Postdoctoral Science Foundation
- Department of Science and Technology of Sichuan Province
- Sichuan University