The chemical composition of secondary organic aerosols regulates transcriptomic and metabolomic signaling in an epithelial-endothelial in vitro coculture
Our findings revealed that the specific effects of SOA on directly exposed epithelial cells are highly dependent on the chemical identity, whereas non directly exposed endothelial cells exhibit more generalized systemic effects with the activation of early stress response genes and the involvement of CVD-related pathways. However, a greater correlation was made between the exposure to the anthropogenic SOA compared to the biogenic SOA. In summary, our study highlights the importance of chemical aerosol composition and the use of cell systems with cell-to-cell interplay on toxicological outcomes.
Authors
- Elena Hartner (ORCID: https://orcid.org/0000-0002-6798-2403)
- Ralf Zimmermann (ORCID: https://orcid.org/0000-0002-6280-3218)
- Christian Kersch
- Simone Schmitz‐Spanke (ORCID: https://orcid.org/0000-0002-0416-8236)
- Christoph Bisig (ORCID: https://orcid.org/0000-0001-9981-1409)
- Jana Pantzke (ORCID: https://orcid.org/0000-0001-5420-8905)
- Elias J. Zimmermann (ORCID: https://orcid.org/0000-0002-8766-180X)
- Svenja Offer (ORCID: https://orcid.org/0009-0005-1159-4769)
- Jürgen Schnelle‐Kreis (ORCID: https://orcid.org/0000-0003-4846-2303)
- Astrid Kiendler‐Scharr (ORCID: https://orcid.org/0000-0003-3166-2253)
- Christopher P. Rüger (ORCID: https://orcid.org/0000-0001-9634-9239)
- Michal Pardo (ORCID: https://orcid.org/0000-0001-6480-1171)
- Yinon Rudich (ORCID: https://orcid.org/0000-0003-3149-0201)
- Thorsten Hohaus (ORCID: https://orcid.org/0000-0001-5722-6244)
- Martin Sklorz (ORCID: https://orcid.org/0000-0001-8043-0024)
- Eric Schneider (ORCID: https://orcid.org/0000-0003-3090-6703)
- Hendryk Czech (ORCID: https://orcid.org/0000-0001-8377-4252)
- Sebastiano Di Bucchianico (ORCID: https://orcid.org/0000-0002-6396-892X)
- Till Ziehm (ORCID: https://orcid.org/0000-0001-5586-3709)
- Thomas Gröger (ORCID: https://orcid.org/0000-0001-9882-7388)
- Sebastian Oeder (ORCID: https://orcid.org/0009-0004-1737-0072)
- Rasha Alsaleh (ORCID: https://orcid.org/0000-0001-7917-5935)
- Stefanie Bauer (ORCID: https://orcid.org/0000-0003-3870-7688)
Institutions
- Forschungszentrum Jülich (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Helmholtz Zentrum München (DE)
- University of Rostock (DE)
- Weizmann Institute of Science (IL)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s12989-024-00600-x
- Citations
- 1
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.31
Funders
- Universität Rostock