Maternal metformin administration during the pre-gestation period improves transient cerebral ischemia injury in male offspring rats
These findings indicated that the metformin intervention via AMPK activation could improve the movement disability, enhance spatial memory, increase neural plasticity, and augment the bioenergetics state and histone acetylation in the hippocampus of the offspring.
Authors
- Fatemeh Nabavizadeh (ORCID: https://orcid.org/0000-0002-9956-6463)
- Ghorbangol Ashabi (ORCID: https://orcid.org/0000-0002-4853-092X)
- Iraj Ahmadi
- Abbas Zareei
- Marjan Nikbakhtzadeh (ORCID: https://orcid.org/0000-0003-0867-3288)
- Mina Ranjbaran (ORCID: https://orcid.org/0000-0003-4791-8911)
- Fradin Sehati
- Reyhaneh Vaali
Institutions
- Medical University of Ilam (IR)
- Ilam University (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Advanced Pharmaceutical Bulletin
- Published
- 2024-09-15
- DOI
- https://doi.org/10.34172/apb.43049
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tehran University of Medical Sciences and Health Services