Knock-out of CD73 delays the onset of HR-negative breast cancer by reprogramming lipid metabolism and is associated with increased tumor mutational burden
CD73 has a significant role in tumorigenesis driving the reprogramming of lipid metabolism through the regulatory loop with PR and PPARγ in epithelial cells of mammary glands. Low CD73 expression/CD73 KO might enhance mutational burden by disrupting this regulatory loop, delaying the onset of HR-negative tumors. Our results support combining therapy targeting the CD73-adenosine axis and tumor lipidome against HR-negative tumors, especially at their earliest developmental stage.
Authors
- Paweł Kamil Serafin (ORCID: https://orcid.org/0000-0003-3535-8099)
- Patrycja Koszałka (ORCID: https://orcid.org/0000-0002-1224-5860)
- Kamila Bulak (ORCID: https://orcid.org/0000-0001-8320-1972)
- Adriana Mika (ORCID: https://orcid.org/0000-0003-2877-5652)
- Barbara Galikowska‐Bogut
- Grzegorz Stasiłojć (ORCID: https://orcid.org/0000-0002-4158-1935)
- Marcin Stanisławowski (ORCID: https://orcid.org/0000-0001-7176-0937)
- Marta Popęda
- Leszek Kalinowski (ORCID: https://orcid.org/0000-0001-7270-1592)
- Anna Joanna Zaczek (ORCID: https://orcid.org/0000-0003-1482-6068)
- Marika Bolcewicz (ORCID: https://orcid.org/0000-0002-5873-2576)
- Agata Zwara (ORCID: https://orcid.org/0000-0003-3373-5751)
- Kamila Jendernalik
- Tomasz Śledziński (ORCID: https://orcid.org/0000-0002-9028-3790)
- Rafał Sądej (ORCID: https://orcid.org/0000-0003-2583-7299)
- Anna Przychodzka
- Wiktoria Laprus
Institutions
- University of Life Sciences in Lublin (PL)
- Gdańsk Medical University (PL)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1016/j.molmet.2024.102035
- Citations
- 4
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- Narodowe Centrum Nauki
- Ministerstwo Edukacji i Nauki
- Gdański Uniwersytet Medyczny