Spatial colocalization and combined survival benefit of natural killer and CD8 T cells despite profound MHC class I loss in non-small cell lung cancer
Tumor-infiltrating NK cells and CD8 T cells jointly affected control of NSCLC tumor progression. Coassociation of NK and CD8 T cells was most evident in MHC-I-bearing tumors, especially in the presence of IFNγ. Frequent colocalization of IFNγ<sup>+</sup> NK cells with other IFNγ<sup>+</sup> lymphocytes in near-neighbor analysis suggests NSCLC lymphocyte activation is coordinately regulated.
Authors
- Nolan A. Wages (ORCID: https://orcid.org/0000-0002-2190-4864)
- Michael G. Brown (ORCID: https://orcid.org/0000-0003-2872-7685)
- Ileana Soto Mauldin (ORCID: https://orcid.org/0000-0002-9318-8342)
- Ryan D. Gentzler (ORCID: https://orcid.org/0000-0002-8983-6677)
- Gabriel F. Hanson (ORCID: https://orcid.org/0009-0003-0202-062X)
- Joseph M. Obeid (ORCID: https://orcid.org/0000-0002-6111-9289)
- Timothy N. J. Bullock (ORCID: https://orcid.org/0000-0001-6141-3261)
- Sepideh Dolatshahi (ORCID: https://orcid.org/0000-0003-0226-0933)
- Craig Lee Slingluff (ORCID: https://orcid.org/0000-0002-6664-4373)
- Nardin Ageeb
- Kate A. Goundry
- Remziye E. Wessel (ORCID: https://orcid.org/0000-0002-8596-4700)
- Mahdin Hossain
- Chad Lehman
Institutions
- Carter Center (US)
- Virginia Commonwealth University (US)
- Temple University Hospital (US)
- Center for Neuroscience and Regenerative Medicine (US)
- University of Virginia (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1136/jitc-2024-009126
- Citations
- 13
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 3.13
Funders
- National Cancer Institute
- National Institute of General Medical Sciences