Cancer-associated fibroblast-derived exosome Leptin promotes malignant biological lineage in pancreatic ductal adenocarcinoma by regulating ABL2 via miR-224-3p
Our results revealed that cancer-associated fibroblasts mediate pancreatic ductal adenocarcinoma development by regulating the miR-224-3p/ABL2 molecular axis through the secretion of the exosomal Leptin.
Authors
- Yan Jin (ORCID: https://orcid.org/0000-0001-5957-7443)
- Yun Jin (ORCID: https://orcid.org/0009-0000-7753-7904)
- Yesheng Chen (ORCID: https://orcid.org/0009-0002-2814-3428)
- Deng Pan (ORCID: https://orcid.org/0000-0002-6475-0463)
- Jing Xu (ORCID: https://orcid.org/0000-0003-1350-4489)
- Yihe Dai
- Weicheng Mou (ORCID: https://orcid.org/0009-0006-8042-0321)
- Li Zhang (ORCID: https://orcid.org/0000-0002-1231-8927)
Institutions
- First People's Hospital of Yunnan Province (CN)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1007/s11033-024-09928-1
- Citations
- 7
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Kunming Medical University