Landiolol for heart rate control in patients with septic shock and persistent tachycardia. A multicenter randomized clinical trial (Landi-SEP)
The ultra-short-acting beta-blocker landiolol was effective in reducing and maintaining HR without increasing vasopressor requirements after 24 h in patients with septic shock and persistent tachycardia. There were no differences in adverse events and clinical outcomes such as 28-day mortality vs. standard of care. The results of this study, in the context of previous trials, do not support a treatment strategy of stringent HR reduction (< 95 bpm) in an unselected septic shock population with persistent tachycardia. Further investigations are needed to identify septic shock patient phenotypes that benefit clinically from HR control.
Authors
- Sebastian Rehberg (ORCID: https://orcid.org/0000-0002-5835-7083)
- Günther Krumpl (ORCID: https://orcid.org/0000-0002-0587-9072)
- Kurt Krejcy
- P Dostál (ORCID: https://orcid.org/0000-0001-9641-5160)
- Tim Rahmel (ORCID: https://orcid.org/0000-0002-7039-6288)
- Martin Unger (ORCID: https://orcid.org/0000-0002-9600-8618)
- Andrea Morelli (ORCID: https://orcid.org/0000-0001-6065-1006)
- Sandra Frank (ORCID: https://orcid.org/0000-0002-1749-0339)
- Michael Joannidis (ORCID: https://orcid.org/0000-0002-6996-0881)
- Matej Podbregar (ORCID: https://orcid.org/0000-0001-7750-415X)
- Rainer Borgstedt (ORCID: https://orcid.org/0000-0002-2870-745X)
- Kadri Tamme (ORCID: https://orcid.org/0000-0001-6110-0417)
- Ingrid Pretsch
- Thomas Pernerstorfer
- Christian Siebers (ORCID: https://orcid.org/0000-0002-9308-7103)
- František Duška (ORCID: https://orcid.org/0000-0003-1559-4078)
- Christoph Klade
- Fabio Guarracino (ORCID: https://orcid.org/0000-0002-2562-0199)
- Radek Cihlář
- Jan Sus (ORCID: https://orcid.org/0009-0003-9832-6526)
- Gíanni Biancofiore (ORCID: https://orcid.org/0000-0002-3755-1434)
- Andreas Schober (ORCID: https://orcid.org/0000-0001-7798-136X)
- Helmut Trimmel (ORCID: https://orcid.org/0000-0002-7327-0699)
- Éva Duliczki
- Nairi Kirchbaumer-Baroian
- Vladimír Černý (ORCID: https://orcid.org/0000-0003-0834-7650)
- Christian Fuchs
Institutions
- University of Pisa (IT)
- Dalhousie University (CA)
- Innsbruck Medical University (AT)
- University of Ljubljana (SI)
- Bielefeld University (DE)
- Hochschule Bielefeld (DE)
- Charles University (CZ)
- Masaryk University (CZ)
- Paracelsus Medical University (AT)
- Universitätsmedizin Greifswald (DE)
- Policlinico Umberto I (IT)
- Tartu University Hospital (EE)
- LMU Klinikum (DE)
- Fachhochschule Wiener Neustadt (AT)
- College of Nursing in Celje (SI)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- AOP Orphan (Austria) (AT)
- Nemocnice České Budějovice (CZ)
- Klinikum Bielefeld (DE)
- University Hospital Hradec Králové (CZ)
- AGO Austria (AT)
- Jósa András Múzeum (HU)
- University Hospital Kralovske Vinohrady (CZ)
- Karl Landsteiner Society (AT)
- Garmisch-Partenkirchen Medical Center (DE)
- Azienda Ospedaliera Universitaria Pisana (IT)
- University of Hradec Králové (CZ)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Intensive Care Medicine
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1007/s00134-024-07587-1
- Citations
- 44
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 17.69
Funders
- Universität Bielefeld
- AOP Orphan