Maternal pregnancy diet quality, night eating, and offspring metabolic health: the GUSTO study
We demonstrated that maternal predominant night-eating behavior and low-quality diet are associated with higher offspring insulin resistance. Maternal low-quality diet and predominant night-eating behavior synergistically interact to influence offspring insulin resistance, particularly among boys. While maternal diet quality and food timing impact the mother's health, their influence on offspring long-term health outcomes through developmental programming is not well understood. Our findings highlight the significance of maternal food timing and calls for further studies on its influence on child health through developmental programming. Targeting both dietary quality and food timing during pregnancy could be a promising intervention strategy.
Authors
- Mary Foong‐Fong Chong (ORCID: https://orcid.org/0000-0003-0587-2505)
- Yap Seng Chong (ORCID: https://orcid.org/0000-0002-7232-8473)
- Johan G. Eriksson (ORCID: https://orcid.org/0000-0002-2516-2060)
- See Ling Loy (ORCID: https://orcid.org/0000-0002-9205-5580)
- Keith M. Godfrey (ORCID: https://orcid.org/0000-0002-4643-0618)
- Jia Ying Toh (ORCID: https://orcid.org/0000-0001-7734-7465)
- Yi Ying Ong (ORCID: https://orcid.org/0000-0003-3072-765X)
- Ling‐Wei Chen (ORCID: https://orcid.org/0000-0002-2661-8752)
- Peter D. Gluckman (ORCID: https://orcid.org/0000-0002-5711-1655)
- Kok Hian Tan (ORCID: https://orcid.org/0000-0003-1945-0266)
- Navin Michael (ORCID: https://orcid.org/0000-0002-6170-2108)
- Yung Seng Lee (ORCID: https://orcid.org/0000-0002-1253-0557)
- Fabian Yap (ORCID: https://orcid.org/0000-0003-1083-7958)
- Mya Thway Tint (ORCID: https://orcid.org/0000-0002-9548-7186)
Institutions
- Agency for Science, Technology and Research (SG)
- University of Helsinki (FI)
- Harvard University (US)
- University of Auckland (NZ)
- National University of Singapore (SG)
- University Hospital Southampton NHS Foundation Trust (GB)
- KK Women's and Children's Hospital (SG)
- NIHR Southampton Biomedical Research Centre (GB)
- Duke-NUS Medical School (SG)
- Folkhälsans Forskningscentrum (FI)
- University of Southampton (GB)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1038/s41390-024-03574-w
- Citations
- 3
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- Medical Research Council