Evaluation of Rho kinase inhibitor effects on neuroprotection and neuroinflammation in an ex-vivo retinal explant model
Y-33075 demonstrates marked neuroprotective and anti-inflammatory effects, surpassing the other tested ROCKis (Y-27632 and H-1152) in preventing RGC death and reducing microglial inflammatory responses. These findings highlight its potential as a therapeutic option for glaucoma.
Authors
- J. Buffault (ORCID: https://orcid.org/0000-0002-4599-9749)
- Annabelle Réaux‐Le Goazigo (ORCID: https://orcid.org/0000-0003-3855-9523)
- Paul Bastelica (ORCID: https://orcid.org/0000-0002-1956-8101)
- Françoise Brignole‐Baudouin (ORCID: https://orcid.org/0000-0002-2006-5384)
- Cécile Delarasse (ORCID: https://orcid.org/0000-0001-9739-4306)
- Christophe Baudouin (ORCID: https://orcid.org/0000-0003-1743-6698)
- Stéphane Melik Parsadaniantz (ORCID: https://orcid.org/0000-0003-2029-9591)
- Élodie Reboussin (ORCID: https://orcid.org/0000-0002-9264-1133)
- Céline Olmière (ORCID: https://orcid.org/0000-0001-7551-1129)
- Ilyes Benmessabih
- Arnaud Cordovilla
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut de la Vision (FR)
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Centre hospitalier national d'ophtalmologie des Quinze-Vingts (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Ambroise-Paré (FR)
- Thea (France) (FR)
Publication Details
- Journal
- Acta Neuropathologica Communications
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1186/s40478-024-01859-z
- Citations
- 4
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- Sorbonne Université