A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities
The biological mechanisms that contribute to cocaine and other substance use disorders involve an array of cortical and subcortical systems. Prior work on the development and maintenance of substance use has largely focused on cortico-striatal circuits, with relatively less attention on alterations within and across large-scale functional brain networks, and associated aspects of the dopamine system. Here, we characterize patterns of functional connectivity in cocaine use disorder and their spatial association with neurotransmitter receptor densities and transporter bindings assessed through PET. Profiles of functional connectivity in cocaine use disorder reliably linked with spatial densities of dopamine D<sub>2/3</sub> receptors across independent datasets. These findings demonstrate that the topography of dopamine receptor densities may underlie patterns of functional connectivity in cocaine use disorder, as assessed through fMRI.
Authors
- Jocelyn A. Ricard (ORCID: https://orcid.org/0000-0001-9605-9389)
- Carrisa V. Cocuzza (ORCID: https://orcid.org/0000-0001-5117-2433)
- Grant L. Jones (ORCID: https://orcid.org/0000-0002-8140-0844)
- Ashlea Segal (ORCID: https://orcid.org/0000-0002-7451-6195)
- Sarah W. Yip (ORCID: https://orcid.org/0000-0003-2293-2864)
- Elvisha Dhamala (ORCID: https://orcid.org/0000-0002-8253-6962)
- Loïc Labache (ORCID: https://orcid.org/0000-0002-5733-0743)
- Sidhant Chopra (ORCID: https://orcid.org/0000-0003-0866-3477)
- Avram J. Holmes (ORCID: https://orcid.org/0000-0001-6583-803X)
Institutions
- Rutgers, The State University of New Jersey (US)
- Northwell Health (US)
- Allen Institute for Brain Science (US)
- Feinstein Institute for Medical Research (US)
- Harvard University (US)
- Yale University (US)
- Orygen Youth Health (AU)
- Rutgers Sexual and Reproductive Health and Rights (NL)
- Orygen (AU)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Communications Biology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1038/s42003-024-06836-9
- Citations
- 9
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- Northwell Health
- Feinstein Institutes for Medical Research
- National Institute of Mental Health