Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease
CKD promotes EndMT and reduces AVF patency. Inhibition of TGF-β signaling, especially disruption of endothelial cell-specific TGF-β signaling, attenuates EndMT and improves AVF patency in mouse AVF. Inhibition of EndMT may be a therapeutic approach of translational significance to improve AVF patency in human patients with CKD.
Authors
- Alan Dardik (ORCID: https://orcid.org/0000-0001-5022-7367)
- Xiaochun Long (ORCID: https://orcid.org/0000-0001-9714-0023)
- Weichang Zhang
- Luis Gonzalez (ORCID: https://orcid.org/0000-0003-2877-7287)
- Ryosuke Taniguchi (ORCID: https://orcid.org/0000-0001-7226-1363)
- Julie E. Goodwin (ORCID: https://orcid.org/0000-0002-8986-8695)
- Chang Shu (ORCID: https://orcid.org/0000-0003-2066-1183)
- Hualong Bai (ORCID: https://orcid.org/0000-0003-4039-414X)
- George Tellides (ORCID: https://orcid.org/0000-0001-7042-8190)
- Carly Thaxton (ORCID: https://orcid.org/0000-0001-9270-8708)
- Yukihiko Aoyagi
- Yuichi Ohashi
- Kathleen A. Martin (ORCID: https://orcid.org/0000-0002-1748-0034)
- Xin Li (ORCID: https://orcid.org/0000-0002-7414-5734)
- Zhuo Li (ORCID: https://orcid.org/0000-0003-3692-8989)
- John Langford (ORCID: https://orcid.org/0000-0002-7307-8664)
- Bogdan Yatsula
Institutions
- Central South University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Augusta University (US)
- Yale University (US)
- VA Connecticut Healthcare System (US)
- University of Tokyo Hospital (JP)
- Cardiovascular Research Center (BR)
- Second Xiangya Hospital of Central South University (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1161/atvbaha.124.320933
- Citations
- 15
- Primary Topic
- Central Venous Catheters and Hemodialysis
- Type
- article
- Field-Weighted Citation Impact
- 11.16