BMP10 reflects pre-capillary pulmonary hemodynamics: association of biomarkers and hemodynamic parameters in pulmonary hypertension
Several biomarkers were strongly associated with mPAP, PAWP, and PVR. BMP10 was the only biomarker strongly associated with mPAP and PVR, but not with PAWP, thus reflecting the pre-capillary PH component. Measurement of BMP10 along with NT-proBNP may aid in diagnosing PH.
Authors
- Michael Coslovsky (ORCID: https://orcid.org/0000-0001-7678-7354)
- André Ziegler (ORCID: https://orcid.org/0000-0002-9838-8087)
- Christine S. Zuern (ORCID: https://orcid.org/0000-0001-6625-284X)
- Gian Voellmin (ORCID: https://orcid.org/0000-0002-3778-1192)
- Maurin Lampart (ORCID: https://orcid.org/0000-0002-3720-2584)
- Elisa Hennings (ORCID: https://orcid.org/0000-0003-2616-5535)
- Otmar Pfister (ORCID: https://orcid.org/0000-0002-6155-5494)
- Stefan Osswald (ORCID: https://orcid.org/0000-0002-9240-6731)
- Michael Kühne (ORCID: https://orcid.org/0000-0002-2937-3711)
- Rebecca E. Paladini (ORCID: https://orcid.org/0000-0002-4502-1978)
- David Conen (ORCID: https://orcid.org/0000-0002-2459-5251)
- Christian Müller (ORCID: https://orcid.org/0000-0002-1120-6405)
- Stefanie Aeschbacher
Institutions
- Roche (Switzerland) (CH)
- University of Basel (CH)
- University Hospital of Basel (CH)
- Population Health Research Institute (CA)
- Hospital Base (CL)
- McMaster University (CA)
Publication Details
- Journal
- Clinical Research in Cardiology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1007/s00392-024-02546-8
- Citations
- 2
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Roche
- Universität Basel