Study on the performance of MoS₂/Au composites for non-enzymatic electrochemical glucose detection

Abstract Glucose concentration is considered an indicator for the diagnosis of diabetes, highlighting the importance of accurate glucose detection. Non-enzymatic electrochemical sensors have been extensively studied for glucose detection applications, with nanocomposites composed of molybdenum disulfide (MoS 2 ) and gold nanoparticles (Au NPs) demonstrating high catalytic activity. In this study, a nanocomposite material composed of MoS 2 and Au NPs (MoS 2 /Au) was synthesized and employed to construct a non-enzymatic electrochemical glucose biosensor. The detection limit of this sensor was explored, reaching as low as 1 mM. Additionally, compared to MoS 2 , the MoS 2 /Au nanocomposite exhibited a higher linear correlation coefficient and sensitivity, with a linear range of 1–25 mM and a sensitivity of 417.556 μA mM −1 cm −2 . The sensor demonstrated excellent performance within the range of human blood glucose concentrations, showing potential for real-time monitoring and precise measurement of glucose levels. Furthermore, it exhibited good stability and reproducibility. These findings indicate the potential applications of MoS 2 /Au in biosensors and immunoassays.