Exploring Tryptophan-based Short Peptides: Promising Candidate for Anticancer and Antimicrobial Therapies
The antibacterial activity of synthesized peptides 3b and 4b was found to be better than the other synthetic peptides. MIC value of roughly 5-50 μg/mL for peptides 3a, 4c, and 4d showed strong antifungal activity against <i>Candida albicans</i>. The synthesized peptides were also evaluated for their anticancer activity against HeLa and MCF-7 cell lines, and found that peptides 3e and 4e were more potent than other peptides against doxorubicin.
Authors
- Adarsh Sahu (ORCID: https://orcid.org/0000-0001-5190-8236)
- Swati Rathore (ORCID: https://orcid.org/0000-0002-7665-5164)
- Neha Rai (ORCID: https://orcid.org/0000-0002-4058-0076)
- Asmita Patil
- Richa Tiwari (ORCID: https://orcid.org/0009-0005-6716-5242)
- Ekta Verma (ORCID: https://orcid.org/0000-0002-5684-1269)
- Shailendra Patil
Institutions
- Swami Vivekanand College of Pharmacy (IN)
- Dr. Hari Singh Gour University (IN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2024-09-19
- DOI
- https://doi.org/10.2174/0118715206260662240613054521
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.31