EFFECTIVENESS OF ATORVASTATIN & ITS COMBINATION WITH MORINGA OLEIFERA IN DIABETIC HYPERLIPIDEMIC RATS

Diabetes mellitus is a metabolic disease due to lessened secretion of insulin from beta cells of the pancreas resulting in abnormal biotransformation of proteins, fats, and carbohydrates. To assess the advantageous outcome of Atorvastatin and its combination with Moringa oleifera in Wistar rats suffering from diabetes mellitus & hyperlipidemia. In a 42-day study, a total of twenty-four Wistar rats were placed in four groups, and in each group, there were six rats. The Control group (Non-Diabetic, Non-Hyperlipidemic) was Group 1, the Control group (Untreated Diabetic & Hyperlipidemic) was Group 2, the Diabetic & Hyperlipidemic group treated with Atorvastatin was Group 3 while the Diabetic & Hyperlipidemic group treated with Atorvastatin & Moringa oleifera in combination was Group-4. In regulating hyperglycemia & hyperlipidemia, combination therapy of Atorvastatin & Moringa oleifera proves a better option. This sums up the evolvement of add-on therapy in managing diabetes mellitus & hyperlipidemia.