KDM4A promotes malignant progression of breast cancer by down-regulating BMP9 inducing consequent enhancement of glutamine metabolism
KDM4A silences BMP9 expression by removing histone methyl groups from the BMP9 gene region, leading to further enhancement of glutamine metabolism, which contributes to malignant tumor progression. In addition, using JIB-04 in combination with exogenous BMP9 could inhibit the malignant progression of breast cancer cells and the growth of tumors more significantly.
Authors
- Yiqing You
- Tao Zeng (ORCID: https://orcid.org/0000-0001-8896-0361)
- Tingting Dang
- Jiafeng Tang
- Yan Zhang (ORCID: https://orcid.org/0000-0002-7983-8396)
- Shiyu Yang
- Yuanxiang Chen (ORCID: https://orcid.org/0009-0001-1624-3109)
- Lan Wei (ORCID: https://orcid.org/0000-0003-1317-8054)
- Haoli Sun
- Tao Yu (ORCID: https://orcid.org/0009-0009-8381-6104)
Institutions
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s12935-024-03504-0
- Citations
- 7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Natural Science Foundation of China