Nine months of bedaquiline, linezolid, levofloxacin, clofazimine, and cycloserine chemotherapy for rifampicin/multidrug-resistant tuberculosis: a multicenter, randomized, open-label non-inferiority trial in China
The 9-month, all-oral regimen is safe and efficacious for the treatment of pulmonary rifampicin/multidrug-resistant tuberculosis. The high incidence of QTc prolongation associated with the use of BDQ highlights the urgent need of routine electrocardiogram monitoring under treatment with BDQ-containing regimens in the Chinese population.
Authors
- Juan Du (ORCID: https://orcid.org/0000-0001-5192-9619)
- Lihui Nie
- Fengling Mi
- Shujun Geng
- Yanhua Song (ORCID: https://orcid.org/0000-0003-4094-3946)
- Xuerui Huang
- Qiping Ge
- Zizheng Lv
- Mengqiu Gao (ORCID: https://orcid.org/0000-0001-5899-1845)
- Yanfang Miao
- Xiaoguang Wu (ORCID: https://orcid.org/0000-0002-5950-1630)
- Yuhong Liu (ORCID: https://orcid.org/0000-0001-6771-011X)
- Hua Li (ORCID: https://orcid.org/0000-0003-3249-0537)
- Hongmei Chen (ORCID: https://orcid.org/0000-0002-2157-4420)
- Hua Wang (ORCID: https://orcid.org/0000-0002-0746-0523)
- Wei Chen (ORCID: https://orcid.org/0000-0002-9550-0109)
- Yanmei Liu
- Yu Chen (ORCID: https://orcid.org/0000-0001-5238-8420)
- Quanying Zhou
- Yu Pang (ORCID: https://orcid.org/0000-0002-4425-9124)
- Fangchao Liu (ORCID: https://orcid.org/0000-0002-5610-4621)
- Rongmei Liu (ORCID: https://orcid.org/0000-0003-3143-9289)
- Mingwu Li (ORCID: https://orcid.org/0000-0003-1394-7845)
- Wei Shu (ORCID: https://orcid.org/0000-0002-4611-6864)
- Li Xie (ORCID: https://orcid.org/0000-0001-6605-2274)
- Liping Ma (ORCID: https://orcid.org/0000-0002-4636-928X)
- Qingshan Cai (ORCID: https://orcid.org/0000-0002-2611-7640)
- Yi Pei
- Mingying Jiang
- Yan Tang
- Guihui Wu
- Xiaohong Chen (ORCID: https://orcid.org/0000-0001-7539-2967)
- Zhongshun Kong
Institutions
- Capital Medical University (CN)
- Hospital of Hebei Province (CN)
- Kunming Third People's Hospital (CN)
- Changsha Central Hospital (CN)
- Beijing Chest Hospital (CN)
- Heilongjiang Center for Tuberculosis Control and Prevention (CN)
- Wuhan Pulmonary Hospital (CN)
- Fuzhou Pulmonary Hospital of Fujian (CN)
- Shenyang Ninth People's Hospital (CN)
- Public Health Clinical Center of Chengdu (CN)
- Hangzhou Red Cross Hospital (CN)
- Pulmonary Hospital of Lanzhou (CN)
- The Sixth People's Hospital of Zhengzhou (CN)
- Chongqing Public Health Medical Center (CN)
- Fourth People's Hospital of Taiyuan (CN)
- Xi'an Chest Hospital (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s12916-024-03633-3
- Citations
- 8
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.11