ACE2 deficiency inhibits thoracic aortic dissection by enhancing SIRT3 mediated inhibition of inflammation and VSCMs phenotypic switch
ACE2 deficiency prevented the development of TAD by inhibiting inflammation and VSMCs phenotypic switch in a SIRT3-dependent manner, suggesting that the ACE2/SIRT3 signaling pathway played a pivotal role in the pathological process of TAD and might be a potential therapeutical target.
Authors
- Hanzhao Zhu (ORCID: https://orcid.org/0000-0002-4987-1339)
- Xinan Qiao (ORCID: https://orcid.org/0009-0001-6365-9086)
- He Sun (ORCID: https://orcid.org/0000-0002-5315-3014)
- Weixun Duan (ORCID: https://orcid.org/0000-0003-4475-7067)
- Linhe Lu (ORCID: https://orcid.org/0000-0002-7970-7898)
- Liqing Jiang (ORCID: https://orcid.org/0000-0002-2595-9109)
- Bin Zhang (ORCID: https://orcid.org/0000-0001-8835-8370)
- Liyun Zhang (ORCID: https://orcid.org/0000-0001-5882-2179)
- Jincheng Liu (ORCID: https://orcid.org/0000-0003-1348-8802)
- Kai Ren (ORCID: https://orcid.org/0000-0002-9005-7590)
- Chao Xue (ORCID: https://orcid.org/0000-0002-7429-2187)
- Xiangyan Peng
- Xiaoya Wang
Institutions
- Xijing Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s10020-024-00926-4
- Citations
- 8
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China