Single-Pot Reaction of Novel Fused Indolizine Derivatives
An unprecedented fused hexacyclic indolizine derivative generated by a single-pot reaction has been developed. This model overcomes the use of catalysts, inefficient atom economy, low yields, and limitations of lengthy steps. Density functional theory calculations reveal the reaction mechanism in which the oxygen molecule plays a crucial role in trapping the penultimate zwitterionic or biradical intermediate to generate the observed products.
Authors
- Qiong Hu (ORCID: https://orcid.org/0000-0001-6360-1813)
- Lei Yu (ORCID: https://orcid.org/0000-0003-3975-8903)
- Yimin Hu (ORCID: https://orcid.org/0000-0002-1638-5393)
- Yajuan Zhang (ORCID: https://orcid.org/0009-0006-1672-4806)
- Ke Zhang (ORCID: https://orcid.org/0000-0001-5972-5127)
- Meng Chang
Institutions
- Anhui Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1021/acs.orglett.4c02882
- Citations
- 6
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- Anhui Provincial Department of Human Resources and Social Security
- National Natural Science Foundation of China