Evaluation of the STANDARD M10 MDR-TB and MTB/NTM assays for the detection of <i>Mycobacterium tuberculosis</i> , rifampicin and isoniazid resistance, and nontuberculous mycobacteria in a low-incidence setting
The molecular diagnostic STANDARD M10 system is highly analogous to the widely established GeneXpert system, which significantly increases the relevance of this evaluation study in the field of rapid detection of <i>M. tuberculosis</i>. To our knowledge, this is the first clinical evaluation describing the performance of the STANDARD M10 MDR-TB and MTB/NTM assays, including an extensive analytical specificity panel (inclusivity and exclusivity) for the detection of <i>M. tuberculosis</i>, drug resistance, and nontuberculous mycobacteria.
Authors
- Bruno Luukinen (ORCID: https://orcid.org/0000-0003-3578-782X)
- Anu Pätäri‐Sampo (ORCID: https://orcid.org/0000-0001-6714-3688)
- Janne Aittoniemi
- Silja Mentula (ORCID: https://orcid.org/0000-0003-3712-1730)
- Terhi Miikkulainen-Lahti
Institutions
- University of Helsinki (FI)
- Tampere University (FI)
- Helsinki University Hospital (FI)
- Finnish Institute for Health and Welfare (FI)
- Fimlab (Finland) (FI)
Publication Details
- Journal
- Journal of Clinical Microbiology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1128/jcm.00402-24
- Citations
- 10
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 3.87
Funders
- Tampereen Tuberkuloosisäätiö
- Filha