Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation

In this Viewpoint, 2024 Albert Lasker Basic Medical Research Award winner Zhijian J. Chen describes his discovery of cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS), a DNA-sensing enzyme that triggers inflammation.

Authors

Zhijian J. Chen (ORCID: https://orcid.org/0000-0002-8475-8251)

Institutions

Howard Hughes Medical Institute (US)
The University of Texas Southwestern Medical Center (US)

Publication Details

Journal: JAMA
Published: 2024-09-19
DOI: https://doi.org/10.1001/jama.2024.17873
Citations: 2
Primary Topic: interferon and immune responses
Type: article
Field-Weighted Citation Impact: 0.48

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article

Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation

Zhijian J. Chen

Sep 19, 2024

2 citations

JAMA

interferon and immune responses

0.48

article

Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation

Zhijian J. Chen

September 19, 2024article en

2 citations

Abstract

JAMAVol. 332(20)

Howard Hughes Medical Institute (US), The University of Texas Southwestern Medical Center (US)

Good health and well-being

Openalex Percentile: Top 35%

interferon and immune responses

0.48

DOI Source OpenAlex

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Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation — Zhijian J. Chen · JAMA (2024) | TGRS Research Map | TGRS