Cell transplantation-mediated dystrophin supplementation efficacy in Duchenne muscular dystrophy mouse motor function improvement demonstrated by enhanced skeletal muscle fatigue tolerance
Cell therapy-mediated dystrophin supplementation efficiently improved DMD muscle functions, as evaluated using newly developed evaluation methods. The enhanced muscle fatigue tolerance in 21-week-old mice was associated with the preferential regeneration of damage-resistant and oxidative fibers, highlighting increased mitochondrial activity, after cell transplantation. These findings significantly contribute to a more in-depth understanding of DMD pathogenesis.
Authors
- Masamichi Yamamoto (ORCID: https://orcid.org/0000-0002-9088-8044)
- Clémence Kiho Bourgeois Yoshioka
- Hidetoshi Sakurai (ORCID: https://orcid.org/0000-0002-5383-9366)
- Megumi Goto (ORCID: https://orcid.org/0000-0002-7079-821X)
- Daiki Watanabe (ORCID: https://orcid.org/0000-0002-1278-3773)
- Nana Takenaka-Ninagawa
- Tomoki Aoyama
- M Miki
Institutions
- Osaka University of Health and Sport Sciences (JP)
- Kyoto University (JP)
- Nagoya City University (JP)
- National Cerebral and Cardiovascular Center (JP)
- Kyoto University Hospital (JP)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s13287-024-03922-x
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Japan Agency for Medical Research and Development
- Research Center Network for Realization of Regenerative Medicine
- Japan Society for the Promotion of Science