Trait-based study predicts glycerol/diol dehydratases as a key function of the gut microbiota of hindgut-fermenting carnivores
Our approach combining metabolite and gene biomarker analysis with metagenomics and phenotypic characterization identified Pdu as a common function of fecal microbiota of captive wild animals shared by few taxa and stratified the potential of fecal microbiota for glycerol/1,2-PD utilization and cobalamin synthesis depending on diet and physiology of the host. This trait-based study suggests that the ability to utilize glycerol/1,2-PD is a key function of hindgut-fermenting carnivores, which does not relate to overall community diversity but links to the potential for cobalamin formation. Video Abstract.
Authors
- Hans‐Joachim Ruscheweyh (ORCID: https://orcid.org/0000-0001-7473-6086)
- Alberto Scoma (ORCID: https://orcid.org/0000-0001-7981-0847)
- Shinichi Sunagawa (ORCID: https://orcid.org/0000-0003-3065-0314)
- Clarissa Schwab (ORCID: https://orcid.org/0000-0002-5443-1602)
- Qing Li (ORCID: https://orcid.org/0000-0003-3317-9396)
- Kim Skalborg Simonsen
- Micael Libertella
- Lærke Hartmann Østergaard
Institutions
- SIB Swiss Institute of Bioinformatics (CH)
- Aarhus University (DK)
- Copenhagen Zoo (DK)
- Vestas (Denmark) (DK)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Microbiome
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s40168-024-01863-4
- Citations
- 5
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Aarhus Universitet
- Eidgenössische Technische Hochschule Zürich
- EMBO
- Norges Miljø- og Biovitenskapelige Universitet