Recruitment of the m6A/m6Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48
Our findings thus uncover a previously unknown mechanism of posttranscriptional regulation in which ZBTB48 co-ordinates RNA-binding of the m6A/m6Am demethylase FTO to control expression of its target RNAs.
Authors
- Mingkun Wu (ORCID: https://orcid.org/0000-0002-0366-3892)
- Edyta Marcon
- Zhaolei Zhang (ORCID: https://orcid.org/0000-0002-7303-6472)
- Guoqing Zhong (ORCID: https://orcid.org/0000-0002-1242-5327)
- Hua Tang (ORCID: https://orcid.org/0000-0002-0177-8864)
- Zuyao Ni (ORCID: https://orcid.org/0009-0003-2783-4777)
- Benjamin J. Blencowe (ORCID: https://orcid.org/0000-0002-4461-0340)
- Giovanni L. Burke (ORCID: https://orcid.org/0000-0002-2113-3406)
- Nujhat Ahmed
- Shuye Pu (ORCID: https://orcid.org/0000-0002-6664-8438)
- Syed Nabeel‐Shah (ORCID: https://orcid.org/0000-0002-4239-7443)
- Shaghayegh Farhangmehr
- Ulrich Braunschweig (ORCID: https://orcid.org/0000-0001-6653-0926)
- Hyunmin Lee (ORCID: https://orcid.org/0000-0002-7970-2050)
- Jack Greenblatt (ORCID: https://orcid.org/0000-0003-1762-2861)
Institutions
- University of Toronto (CA)
Publication Details
- Journal
- Genome biology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s13059-024-03392-7
- Citations
- 13
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- University of Toronto
- Central European Institute of Technology
- Canadian Institutes of Health Research