Construction of Lactones via Ligand-Enabled Ni-Catalyzed Alkene Hydroxylarylation/Lactonization
Here, we report the preparation of lactones via Ni-catalyzed alkene hydroxylarylation and sequential intramolecular lactonization with O2 as a green oxidant and oxygen source. The bulky 1,3-diketone ligand is crucial by enabling Ni-catalyzed hydroxylarylation of alkenes, providing numerous phthalide and furanone derivatives with high efficiency under mild conditions. The synthetic value of this methodology was further demonstrated by the efficient synthesis of typhaphthalide and a monoamine oxidase B inhibitor.
Authors
- Daoming Wang (ORCID: https://orcid.org/0000-0003-4623-8527)
- Yong Tang (ORCID: https://orcid.org/0000-0002-5435-9938)
- Yi‐Chen Wu (ORCID: https://orcid.org/0000-0002-9199-1203)
- Peng Wang (ORCID: https://orcid.org/0000-0002-6442-3008)
- Yu-Qing He (ORCID: https://orcid.org/0009-0008-9191-1745)
Institutions
- Hangzhou Normal University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1021/acs.orglett.4c03108
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Program of Shanghai Academic Research Leader