Base-Promoted Tandem Cyclization of 2-(Indol-3-yl)naphthoquinones with Benzamidines toward Polysubstituted Pyrimido[4,5-<i>b</i>]indoles
A novel and unique approach for the construction of polysubstituted pyrimido[4,5-<i>b</i>]indoles from 2-(indol-3-yl)naphthoquinones and benzamidines is described. Our strategy, promoted by an inorganic base, involves the ring opening and recyclization of naphthoquinone and produces three nitrogen heterocyclic rings via multiple C-N bond formations in one pot under transition-metal-free conditions.
Authors
- Bin Tan (ORCID: https://orcid.org/0000-0001-8219-9970)
- Shanping Chen
- Guo‐Jun Deng (ORCID: https://orcid.org/0000-0003-2759-0314)
- Xinlin Zhou (ORCID: https://orcid.org/0000-0002-3530-0922)
- Kai Hu (ORCID: https://orcid.org/0000-0003-1436-9522)
- Chao Zhang (ORCID: https://orcid.org/0009-0008-2674-344X)
Institutions
- Xiangtan University (CN)
- Henan Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1021/acs.orglett.4c02847
- Citations
- 2
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Henan Normal University
- National Natural Science Foundation of China
- Ministry of Education of the People's Republic of China
- Natural Science Foundation of Hunan Province
- Science and Technology Program of Hunan Province