Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight
The findings demonstrate that UTI exerts transformative regulatory effects on the NLRP3 inflammasome in epilepsy models. This intervention effectively suppresses neuroinflammation, lessens seizure severity and susceptibility, and ameliorates epilepsy-related BBB dysfunction and cognitive impairments.
Authors
- Yuzhu Ma (ORCID: https://orcid.org/0000-0001-6291-2812)
- Huan Wang (ORCID: https://orcid.org/0000-0002-0100-7875)
- Xinlei Yang
- Xiangping Xu
- Dongmei Jin
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38050
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Harbin Medical University
- National Natural Science Foundation of China