Copper-Catalyzed Oxyfluorosulfonylation of β,γ-Unsaturated Oximes with Sulfur Dioxide and Selectfluor for Isoxazoline-Functionalized Aliphatic Sulfonyl Fluorides
In this report, we describe a copper-catalyzed cascade reaction involving oxygen radical-induced cyclization/SO<sub>2</sub> insertion/fluorination of β,γ-unsaturated oximes with sulfur dioxide and Selectfluor under mild conditions for the synthesis of isoxazoline-functionalized aliphatic sulfonyl fluorides. The synthetic potential of these compounds has been evaluated through diverse SuFEx reactions.
Authors
- Zhi-Min Yan
- Qi Lin (ORCID: https://orcid.org/0000-0002-3786-3593)
- Wei Li (ORCID: https://orcid.org/0000-0001-5069-5945)
- Jiali Liu (ORCID: https://orcid.org/0000-0001-6014-758X)
- Lijin Wang
- Huijie Du
Institutions
- Hebei University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1021/acs.joc.4c00616
- Citations
- 4
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.83
Funders
- Natural Science Foundation of Hebei Province
- Hebei University