A Comparative Study of Cystatin C and Creatinine as a Preliminary Marker of Nephropathy in Type 2 Diabetic Patients

Background: Type 2 diabetes disorder (T2DD) is one of the most common disorder in societies, and its causes are genetic and acquired. This disorder is characterized by an increase in the concentration of glucose in the blood. High concentrations of glucose in the blood for long periods lead to complications, the most important of which is diabetic nephropathy (DNP), which is characterized by the gradual loss of the kidney's filtration function.Material and methods: The present study was designed based on collecting twenty patients with newly DNP (as first group) and twenty healthy individuals (as second group). The levels of HbA1c, Creatinine and Cystatin C of all study individuals were measured using Chromatographic assay method, Kinetic colorimetric method and Immunoturbidimetric assay techniques respectively.Results: This study used the t-test statistical method to compare groups as well as sensitivity and specificity based on HbA1c, creatinine and Cystatin C biomarkers. The current study showed a higher the HbA1c percentage, creatinine level and Cystatin C level in the first group compared to the second group. On the other hand, the current study showed that Cystatin C has greater sensitivity and specificity than creatinine towards the DNP disease.Conclusion: The current study concluded by stating the importance of the role of Cystatin C as an early indicator of DNP disease, as the current study proved that Cystatin C has greater sensitivity and specificity than creatinine towards DNP disease