NCS-Mediated Direct C(sp<sup>3</sup>)–H Oxygenation of 2-Methylindoles Using Water as the Oxygen Source
In continuation of our research interest in the green oxidation of indoles, we further explore the direct oxidation of 2-methylindoles to 2-formyl indoles promoted by NCS and associated with H<sub>2</sub>O as the oxygen source. This methodology was demonstrated to be a robust protocol consisting of chlorination, S<sub>N</sub>2', and oxidation processes, and presents a reasonably broad substrate scope and excellent functional group tolerance, thus enabling the preparation of high added-value versatile building blocks susceptible to further functionalization.
Authors
- Yaoyao Liu (ORCID: https://orcid.org/0000-0002-5903-8527)
- Jun Xu (ORCID: https://orcid.org/0000-0003-1972-508X)
- Yuling Luo (ORCID: https://orcid.org/0000-0002-0117-4614)
- Xiaoyi Liu (ORCID: https://orcid.org/0009-0006-5862-2031)
- Fan Zhang (ORCID: https://orcid.org/0000-0002-7741-9075)
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
- Guizhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1021/acs.joc.4c01753
- Citations
- 5
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- National Natural Science Foundation of China