QSM-detected iron accumulation in the cerebellar gray matter is selectively associated with executive dysfunction in non-demented ALS patients
Iron accumulation within the cerebellar GM, particularly in the cerebellar cortices, may be associated with executive functioning deficits in non-demented ALS patients. Therefore, QSM-based measures could be useful for identifying the neural correlates of extra-motor cognitive deficits in ALS patients.
Authors
- Claudia Cinnante (ORCID: https://orcid.org/0000-0002-8388-2074)
- Valeria Elisa Contarino (ORCID: https://orcid.org/0000-0002-8922-657X)
- Vincenzo Silani (ORCID: https://orcid.org/0000-0002-7698-3854)
- Silvia Casale (ORCID: https://orcid.org/0000-0002-6286-7537)
- Claudia Morelli (ORCID: https://orcid.org/0000-0003-4027-958X)
- Nicola Ticozzi (ORCID: https://orcid.org/0000-0001-5963-7426)
- Silvia Torre (ORCID: https://orcid.org/0000-0002-2039-3644)
- Alessio Maranzano (ORCID: https://orcid.org/0000-0002-3642-9584)
- Federica Solca (ORCID: https://orcid.org/0000-0002-3274-3963)
- Federico Verde (ORCID: https://orcid.org/0000-0002-3977-6995)
- Barbara Poletti (ORCID: https://orcid.org/0000-0003-4398-2051)
- Alberto Doretti (ORCID: https://orcid.org/0000-0002-1015-7365)
- Edoardo Nicolò Aiello (ORCID: https://orcid.org/0000-0001-8902-7733)
- Giorgio Conte (ORCID: https://orcid.org/0000-0002-1562-7389)
- Fabio Maria Triulzi (ORCID: https://orcid.org/0000-0002-5428-7217)
- Eleonora Colombo (ORCID: https://orcid.org/0000-0001-9062-4850)
- Chunlei Liu (ORCID: https://orcid.org/0000-0001-8816-4832)
- B. Curti
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Ferrari (Italy) (IT)
- University of California, Berkeley (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.3389/fneur.2024.1426841
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Milano
- Dipartimenti di Eccellenza
- European Commission
- Ministero della Salute