Astaxanthin attenuates glucose-induced liver injury in largemouth bass: role of p38MAPK and PI3K/Akt signaling pathways
Astaxanthin exhibited a protective effect against apoptosis by regulating p38MAPK/bcl-2/caspase-3 pathway, and ameliorated insulin resistance by activating the PTP1B/PI3K/Akt pathway. This study elucidated the mechanism of astaxanthin in the liver injury of largemouth bass from a new perspective and provided a new target for the treatment of insulin resistance.
Authors
- Xin Cui (ORCID: https://orcid.org/0000-0002-2141-4400)
- Sihan Lin (ORCID: https://orcid.org/0000-0002-4422-9275)
- Wei Zhao (ORCID: https://orcid.org/0000-0003-2296-9050)
- Xuanshu He (ORCID: https://orcid.org/0009-0001-1930-4368)
- Baoyang Chen
- Jin Niu (ORCID: https://orcid.org/0009-0007-9217-0726)
- Yucai Guo
- Anqi Chen (ORCID: https://orcid.org/0000-0002-9480-9059)
- Jian Zhong (ORCID: https://orcid.org/0000-0003-1026-8695)
- Zhihong Liao (ORCID: https://orcid.org/0000-0003-1257-0767)
Institutions
- Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s13578-024-01304-7
- Citations
- 4
- Primary Topic
- Aquaculture Nutrition and Growth
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China
- Novo Nordisk Foundation Center for Basic Metabolic Research
- Medical Science and Technology Foundation of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province