Identification of Genetic Loci Associated With Intracerebral Hemorrhage Using a Multitrait Analysis Approach
Genome-wide association studies (GWASs) have only 2 loci associated with spontaneous intracerebral hemorrhage (ICH): APOE for lobar and 1q22 for nonlobar ICH. We aimed to discover new loci through an analysis that combines correlated traits (multi-trait analysis of GWAS [MTAG]) and explore a gene-based analysis, transcriptome-wide association study (TWAS), and proteome-wide association study (PWAS) to understand the biological mechanisms of spontaneous ICH providing potential therapeutic targets.
Authors
- Miquel Lledós (ORCID: https://orcid.org/0000-0001-8832-789X)
- Alba Sierra‐Marcos (ORCID: https://orcid.org/0000-0001-6570-9318)
- Jara Cárcel‐Márquez (ORCID: https://orcid.org/0000-0002-6949-0699)
- Victoria Ros‐Castelló (ORCID: https://orcid.org/0000-0002-9523-3012)
- Jesús M. Martín‐Campos (ORCID: https://orcid.org/0000-0003-0414-037X)
- Laia Llucià‐Carol (ORCID: https://orcid.org/0000-0002-7732-0665)
- Joan Martí‐Fàbregas (ORCID: https://orcid.org/0000-0001-9229-8649)
- Natàlia Cullell (ORCID: https://orcid.org/0000-0001-5118-1014)
- Elena Muiño (ORCID: https://orcid.org/0000-0001-5839-7328)
- Ana Aguilera‐Simón (ORCID: https://orcid.org/0000-0003-1428-8212)
- Cristina Gallego-Fábrega (ORCID: https://orcid.org/0000-0003-3229-5512)
- Israel Fernández‐Cadenas (ORCID: https://orcid.org/0000-0003-4821-2363)
- Paula Villatoro-González
Institutions
- Cardiovascular Research Center (BR)
Publication Details
- Journal
- Neurology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1212/wnl.0000000000209666
- Citations
- 6
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.30