Palbociclib in Solid Tumor Patients With Genomic Alterations in the cyclinD-cdk4/6-INK4a-Rb Pathway: Results From National Cancer Institute-Children's Oncology Group Pediatric Molecular Analysis for Therapy Choice Trial Arm I (APEC1621I)
The CDK4/6 inhibitor palbociclib at 75 mg/m<sup>2</sup> orally daily was tolerable in this heavily pretreated cohort. No objective responses were observed in this histology-agnostic biomarker-selected population with treatment-refractory solid tumors, demonstrating that pathway alteration alone is insufficient in pediatric cancers to generate a response to palbociclib monotherapy.
Authors
- Rajen J. Mody (ORCID: https://orcid.org/0000-0001-5574-1779)
- Jin Piao (ORCID: https://orcid.org/0000-0003-0516-6280)
- Lauren Saguilig
- Sinchita Roy‐Chowdhuri (ORCID: https://orcid.org/0000-0002-9447-7701)
- Joel M. Reid (ORCID: https://orcid.org/0000-0003-2872-3123)
- David R. Patton (ORCID: https://orcid.org/0000-0003-3855-0166)
- D. Williams Parsons (ORCID: https://orcid.org/0000-0002-8775-3501)
- Nita L. Seibel (ORCID: https://orcid.org/0000-0001-6259-7955)
- Brenda J. Weigel (ORCID: https://orcid.org/0000-0003-1080-1402)
- Elizabeth Fox (ORCID: https://orcid.org/0000-0002-9998-5326)
- Katherine A. Janeway (ORCID: https://orcid.org/0000-0001-6000-3594)
- Margaret E. Macy (ORCID: https://orcid.org/0000-0001-6446-9180)
- Margaret Mooney (ORCID: https://orcid.org/0000-0002-6998-8331)
- Todd A. Alonzo (ORCID: https://orcid.org/0000-0002-6772-6581)
- Brent D. Coffey (ORCID: https://orcid.org/0009-0009-2047-5699)
- James V. Tricoli (ORCID: https://orcid.org/0000-0003-3975-8516)
- Stacey L. Berg (ORCID: https://orcid.org/0000-0003-2832-9994)
- Naoko Takebe (ORCID: https://orcid.org/0000-0002-5790-4954)
- Douglas S. Hawkins (ORCID: https://orcid.org/0000-0003-3602-1375)
- P. Mickey Williams (ORCID: https://orcid.org/0000-0002-3309-5988)
Institutions
- University of Southern California (US)
- Seattle Children's Hospital (US)
- National Institutes of Health (US)
- University of Minnesota (US)
- St. Jude Children's Research Hospital (US)
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- University of Washington (US)
- University of Michigan (US)
- Children's Hospital Colorado (US)
- Mayo Clinic in Arizona (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Children's Cancer Center (US)
- C. S. Mott Children's Hospital (US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1200/po-24-00418
- Citations
- 8
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 3.35