Randomized Phase III SIERRA Trial of <sup>131</sup> I-Apamistamab Before Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care for Relapsed/Refractory AML
The <sup>131</sup>I-apamistamab-led regimen was associated with a higher dCR rate than conventional care in older patients with RR AML. <sup>131</sup>I-apamistamab was well tolerated and could address an unmet need in this population.
Authors
- Elaina Haeuber
- Johnnie J. Orozco (ORCID: https://orcid.org/0000-0002-1361-4680)
- George L. Chen (ORCID: https://orcid.org/0000-0002-7036-2109)
- Neeta D. Pandit-Taskar (ORCID: https://orcid.org/0000-0003-1551-2036)
- Patrick J. Stiff (ORCID: https://orcid.org/0000-0001-8265-9340)
- Jennifer Spross (ORCID: https://orcid.org/0009-0009-3863-1514)
- Vijay Reddy (ORCID: https://orcid.org/0000-0003-4638-8277)
- Michael Schuster (ORCID: https://orcid.org/0000-0003-2975-8969)
- Avinash Desai
- Parameswaran Hari (ORCID: https://orcid.org/0000-0002-8800-297X)
- Hannah Choe (ORCID: https://orcid.org/0000-0002-2849-2989)
- James M. Foran (ORCID: https://orcid.org/0000-0003-1673-1708)
- Moshe Yair Levy (ORCID: https://orcid.org/0000-0002-2570-6128)
- John M. Pagel (ORCID: https://orcid.org/0000-0001-5745-8125)
- Hillard Michael Lazarus (ORCID: https://orcid.org/0000-0002-1159-5607)
- Koen van Besien (ORCID: https://orcid.org/0000-0002-8164-6211)
- Arjun Law (ORCID: https://orcid.org/0000-0002-9251-3609)
- Pashna N. Munshi (ORCID: https://orcid.org/0000-0002-8079-9443)
- Stuart Seropian (ORCID: https://orcid.org/0000-0001-5168-8325)
- Scott D. Rowley (ORCID: https://orcid.org/0000-0002-3299-835X)
- Mitchell Sabloff (ORCID: https://orcid.org/0000-0002-0122-6138)
- Kathleen McNamara (ORCID: https://orcid.org/0000-0002-7020-1663)
- Boglarka Gyurkocza (ORCID: https://orcid.org/0000-0002-2933-2119)
- Sergio A. Giralt (ORCID: https://orcid.org/0000-0003-1944-5053)
- Rachel J. Cook (ORCID: https://orcid.org/0000-0001-7005-036X)
- Benjamin Tomlinson (ORCID: https://orcid.org/0000-0002-2407-0973)
- Madhuri Vusirikala (ORCID: https://orcid.org/0000-0002-5804-3738)
- Brenda M. Sandmaier (ORCID: https://orcid.org/0000-0002-9767-9739)
- Nebu Koshy (ORCID: https://orcid.org/0000-0002-5119-7611)
- Mark Robert Litzow (ORCID: https://orcid.org/0000-0002-9816-6302)
- Zaid Al‐Kadhimi (ORCID: https://orcid.org/0000-0002-6820-8786)
- Sunil Abhyankar (ORCID: https://orcid.org/0000-0002-8578-1226)
- Karilyn Larkin (ORCID: https://orcid.org/0000-0002-1898-9836)
- Partow Kebriaei
- Camille N. Abboud (ORCID: https://orcid.org/0000-0002-5469-8534)
- Margarida Silverman
- Rajneesh Nath
- Akash Nahar
- James A. MacDougall
- Katarzyna Jamieson (ORCID: https://orcid.org/0009-0004-0947-0874)
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Iowa (US)
- Roswell Park Comprehensive Cancer Center (US)
- Loyola University Medical Center (US)
- Froedtert Hospital (US)
- Hackensack University Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Ottawa (CA)
- Oregon Health & Science University (US)
- Georgetown University (US)
- University of Washington (US)
- Medical College of Wisconsin (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- University Hospitals of Cleveland (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Texas Oncology (US)
- Ottawa Hospital (CA)
- Jacksonville College (US)
- WinnMed (US)
- MedStar Georgetown University Hospital (US)
- Princess Margaret Cancer Centre (CA)
- Yale Cancer Center (US)
- Yale University (US)
- Fred Hutch Cancer Center (US)
- The University of Kansas Cancer Center (US)
- CancerCare (US)
- Mayo Clinic in Arizona (US)
- Loxo Oncology at Lilly (United States) (US)
- Actinium Pharmaceuticals (United States) (US)
- Mayo Clinic in Florida (US)
- Baylor Scott & White Health (US)
- Banner MD Anderson Cancer Center
- Ottawa Hospital Research Institute (CA)
- The Ohio State University (US)
- Case Western Reserve University (US)
- University of Nebraska Medical Center (US)
- Stony Brook University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1200/jco.23.02018
- Citations
- 12
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Abbott Laboratories
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- Fred Hutchinson Cancer Research Center
- Spectrum Pharmaceuticals
- Celgene
- Karyopharm Therapeutics
- Therakos
- Case Western Reserve University
- CSL Behring
- Regeneron Pharmaceuticals
- Taiho Pharmaceutical
- Actinium Pharmaceuticals
- Ironwood Pharmaceuticals, Incorporated
- Jazz Pharmaceuticals
- TG Therapeutics
- Astex Pharmaceuticals
- MEI Pharma
- BeiGene
- CTI Biopharma
- Incyte
- Syndax Pharmaceuticals
- Cardinal Health
- Moderna
- MacroGenics
- Seagen
- Y-mAbs Therapeutics
- Astellas Pharma
- Ministry of Minority Affairs
- Servier
- Swedish Orphan Biovitrum
- MorphoSys
- Ipsen
- Genentech
- Pharmacyclics
- Sanofi Pasteur