Huang-Jin-Shuang-Shen Decoction promotes CD8+ T-cell-mediated anti-tumor immunity by regulating chemokine CXCL10 in gastric cancer
The present study aimed to investigate the pharmacological mechanism of the HJSS Decoction and its potential clinical application in inhibiting gastric cancer in mice. HJSS Decoction can cooperate with 5-FU to inhibit gastric cancer, and the optimal dose is medium. HJSS Decoction exerts anti-tumor immunity by activating the NFκB-related signaling pathway and promoting the expression of CXCL10, which in turn recruits CD8+ T cells into the tumor immune microenvironment. Overall, these findings provide valuable evidence for the potential clinical application of HJSS Decoction.
Authors
- Weiyu Liang (ORCID: https://orcid.org/0000-0002-6757-0556)
- Zhengqi Zhao
- Yewen Feng
- Chuqi Yang
- Xuefei Xu (ORCID: https://orcid.org/0000-0002-2009-0483)
- Guangji Zhang (ORCID: https://orcid.org/0000-0003-4525-9422)
- Tao Jiang
- Mengting Wu (ORCID: https://orcid.org/0000-0002-7111-8028)
- XU Chu-yun
Institutions
- Zhejiang Chinese Medical University (CN)
- Soochow University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1016/j.phymed.2024.156065
- Citations
- 9
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.54
Funders
- National Natural Science Foundation of China