The Impact of Radiation Dose and Tumour Burden on Outcomes in Hepatocellular Carcinoma: 11-Year Experience in a 413-Patient Cohort Treated with Yttrium-90 Resin Microsphere Radioembolisation
Treatment outcomes for unresectable HCC using Y-90 RE were favourable. Incorporating tumour burden and distribution improved prognostication. Patients who received tumour absorbed dose above 150 Gy had better OS. Patients who subsequently received curative therapies after being downstaged by Y-90 RE had remarkable clinical outcomes.
Authors
- Richard Lo
- Lu Yang (ORCID: https://orcid.org/0000-0003-2532-8638)
- Kaina Chen (ORCID: https://orcid.org/0000-0002-0778-7294)
- Han Chong Toh (ORCID: https://orcid.org/0000-0003-0642-3453)
- Daniel Yang Yao Peh
- Hian Liang Huang (ORCID: https://orcid.org/0000-0001-5837-9162)
- Sean Xuexian Yan (ORCID: https://orcid.org/0000-0001-6178-7386)
- Wan Ying Chan (ORCID: https://orcid.org/0009-0005-3557-6100)
- Sue Ping Thang (ORCID: https://orcid.org/0000-0002-7229-8737)
- Brian K. P. Goh (ORCID: https://orcid.org/0000-0001-8218-4576)
- Chow Wei Too (ORCID: https://orcid.org/0000-0002-0073-1554)
- Pik‐Eu Chang (ORCID: https://orcid.org/0000-0002-2702-8412)
- Ashley W.Y. Ng
- Nanda Venkatanarasimha (ORCID: https://orcid.org/0000-0001-8011-2368)
- Kelvin Siu Hoong Loke (ORCID: https://orcid.org/0000-0002-5339-5435)
- Aaron Kian Ti Tong (ORCID: https://orcid.org/0000-0002-7703-8707)
- Apoorva Gogna (ORCID: https://orcid.org/0000-0003-2610-525X)
- David Chee Eng Ng (ORCID: https://orcid.org/0000-0001-8554-3036)
- Timothy S K Ong
- Pierce K. H. Chow
- Fiona N.N. Moe
- Eng Xuan Yeo
Institutions
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- Singapore General Hospital (SG)
- Duke-NUS Medical School (SG)
- National Cancer Centre Singapore (SG)
Publication Details
- Journal
- Liver Cancer
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1159/000541539
- Citations
- 6
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.22