Unveiling the Enigma of Statin-Induced Necrotizing Autoimmune Myopathy: A Comprehensive Case Analysis and Pathogenic Insights

Statins are widely prescribed to patients for their efficiency in cholesterol management. However, they carry the risk of inducing a relatively rare, serious, and potentially life-threatening condition known as statin-induced necrotizing autoimmune myopathy (SINAM). This case report provides an in-depth analysis of SINAM, focusing on its epidemiology, clinical presentation, and the challenges involved in accurate diagnosis. In addition, we review evolving theories addressing its pathogenesis and current therapeutic approaches. This report identifies the need for early diagnosis and intervention and recommends a multidisciplinary approach to optimize patient outcomes. This article also highlights the need for further research studies to enhance our understanding of SINAM and its management.

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Publication Details

Journal
Cureus
Published
2024-09-19
DOI
https://doi.org/10.7759/cureus.69751
Primary Topic
Inflammatory Myopathies and Dermatomyositis
Type
article
Field-Weighted Citation Impact
0.00
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article

Unveiling the Enigma of Statin-Induced Necrotizing Autoimmune Myopathy: A Comprehensive Case Analysis and Pathogenic Insights

Swati Baraiya, Praneeth Ulavala, Hari Chandana Kalangi, Hemalatha Bhoompally et al.
Cureus
Inflammatory Myopathies and Dermatomyositis
article

Unveiling the Enigma of Statin-Induced Necrotizing Autoimmune Myopathy: A Comprehensive Case Analysis and Pathogenic Insights

Swati Baraiya, Praneeth Ulavala, Hari Chandana Kalangi, Hemalatha Bhoompally, Abhishek Vadher
article en

Abstract

Statins are widely prescribed to patients for their efficiency in cholesterol management. However, they carry the risk of inducing a relatively rare, serious, and potentially life-threatening condition known as statin-induced necrotizing autoimmune myopathy (SINAM). This case report provides an in-depth analysis of SINAM, focusing on its epidemiology, clinical presentation, and the challenges involved in accurate diagnosis. In addition, we review evolving theories addressing its pathogenesis and current therapeutic approaches. This report identifies the need for early diagnosis and intervention and recommends a multidisciplinary approach to optimize patient outcomes. This article also highlights the need for further research studies to enhance our understanding of SINAM and its management.

CureusVol. 16(9)
North Shore University Hospital (US), North Shore Hospital (NZ), Kamineni Hospitals (IN), Yashoda Hospital (IN), Bombay Hospital (IN), Narayan Medical College and Hospital (IN)
Zero hunger
Openalex Percentile: Top 76%
Inflammatory Myopathies and Dermatomyositis
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