The impact of age and renal function on the pharmacokinetics and protein binding characteristics of fludarabine in paediatric and adult patients undergoing allogeneic haematopoietic stem cell transplantation conditioning
Patient age and GFR are predictors of unbound F-Ara-A CLu. This has the potential to impact dose requirements. Dose individualisation by target concentration intervention will be facilitated by this model once it is externally validated.
Authors
- Stephen Robert Larsen (ORCID: https://orcid.org/0000-0002-4867-291X)
- Christa E. Nath (ORCID: https://orcid.org/0000-0002-1013-3646)
- Melissa Gabriel
- Jason Chung (ORCID: https://orcid.org/0000-0002-7385-0474)
- K Nath (ORCID: https://orcid.org/0009-0006-7442-1555)
- Peter J. Shaw (ORCID: https://orcid.org/0000-0003-0101-4482)
- Sebastian P. A. Rosser (ORCID: https://orcid.org/0000-0002-0203-4904)
- Steven J. Keogh
- John Gibson
Institutions
- The University of Sydney (AU)
- Royal Prince Alfred Hospital (AU)
- Children's Hospital at Westmead (AU)
- Western Sydney University (AU)
Publication Details
- Journal
- European Journal of Clinical Pharmacology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1007/s00228-024-03751-0
- Citations
- 6
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 2.63
Funders
- Australian Government
- Cancer Institute NSW
- University of Sydney
- Kids Cancer Alliance