Blue Light-Induced Accelerated Formation of Melanolipofuscin-Like Organelles in Japanese Quail RPE Cells: An Electron Microscopic Study
It is assumed that the decrease in the number of melanosomes in the RPE during aging and photo-oxidative stress is associated with their fusion with lipofuscin granules and subsequent degradation of melanin by reactive oxygen species formed in melanolipofuscin-like granules. The disappearance of melanin deprives the RPE cells of light-filtering and antioxidant protection, and significantly increases the risk of their oxidative stress.
Authors
- M. A. Yakovleva (ORCID: https://orcid.org/0000-0003-4243-2787)
- М. А. Оstrovsky (ORCID: https://orcid.org/0000-0003-4350-2812)
- Natalia B. Serejnikova (ORCID: https://orcid.org/0000-0002-4097-1552)
- А. Е. Донцов (ORCID: https://orcid.org/0000-0002-8367-5008)
- Н. Н. Трофимова (ORCID: https://orcid.org/0000-0001-8951-7134)
- Pavel Žák
Institutions
- Sechenov University (RU)
- Institute of Biochemical Physics NM Emanuel (RU)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1167/iovs.65.11.31
- Citations
- 2
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Ministry of Science and Higher Education of the Russian Federation