Exploring the Metabolism of Flubrotizolam, a Potent Thieno-Triazolo Diazepine, Using Human Hepatocytes and High-Resolution Mass Spectrometry
We suggest detecting flubrotizolam and its hydroxylated metabolites as markers of consumption after the glucuronide hydrolysis of biological samples. The results are consistent with the in vivo metabolism of brotizolam, a medically used benzodiazepine and a chloro-phenyl analog of flubrotizolam.
Authors
- Francesco Paolo Busardò (ORCID: https://orcid.org/0000-0002-3082-4532)
- Volker Auwärter (ORCID: https://orcid.org/0000-0002-1883-2804)
- Johannes Kutzler (ORCID: https://orcid.org/0000-0002-8693-9312)
- Jérémy Carlier (ORCID: https://orcid.org/0000-0003-3332-9518)
- Diletta Berardinelli (ORCID: https://orcid.org/0009-0001-3005-5825)
- Prince Sellase Gameli (ORCID: https://orcid.org/0009-0001-3194-3250)
Institutions
- Marche Polytechnic University (IT)
- University of Freiburg (DE)
Publication Details
- Journal
- Metabolites
- Published
- 2024-09-19
- DOI
- https://doi.org/10.3390/metabo14090506
- Citations
- 3
- Primary Topic
- Forensic Toxicology and Drug Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05