Increased cancellous bone mass accompanies decreased cortical bone mineral density and higher axial deformation in femurs of leptin-deficient obese mice
Leptin deficient ob/ob mice have a softer cortical bone in the distal femur metaphysis but an excessive amount of cancellous bone, possibly as a response to increased deformation of the bones during axial loading. Both FEA and direct X-ray and electron microscopy imaging suggest that the morphology and micro-architecture of ob/ob mice have inferior biomechanical properties suggestive of a reduced mechanical competence.
Authors
- Maria Teresa Zenzes
- S. Tsitsilonis (ORCID: https://orcid.org/0000-0002-6529-6864)
- Frank Graef (ORCID: https://orcid.org/0000-0002-0435-9059)
- Paul Zaslansky (ORCID: https://orcid.org/0000-0002-8714-4992)
- Ricarda Seemann (ORCID: https://orcid.org/0000-0001-5752-070X)
- Georg N. Duda (ORCID: https://orcid.org/0000-0001-7605-3908)
- Ye Wei (ORCID: https://orcid.org/0000-0003-1994-5664)
- A Garbe
Institutions
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1016/j.jmbbm.2024.106745
- Citations
- 2
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- Deutsche Forschungsgemeinschaft