Inverse association between the molecular spreading of IgE to grass pollen and the IgE response to Dermatophagoides pteronyssinus among children with seasonal allergic rhinitis
The main finding of this study was the detection of an inverse association, never described in the literature, between the molecular spreading of the IgE response to <i>Phleum pratense</i> and the IgE response to <i>D.pt</i>. This led us to speculate on the etiopathogenetic hypothesis according to which, among the majority of pollen allergic patients, a strong and molecularly diversified IgE response may be limited to pollen allergens and may be preventing or contrasting the development of an equally strong and diversified IgE sensitization to <i>D.pt</i> molecules. The biological mechanisms underlying this phenomenon deserve to be investigated.
Authors
- Stephanie Dramburg (ORCID: https://orcid.org/0000-0002-9303-3260)
- Giovanna De Castro (ORCID: https://orcid.org/0000-0003-1838-0243)
- Giampaolo Ricci (ORCID: https://orcid.org/0000-0002-3660-8750)
- Carlo Caffarelli (ORCID: https://orcid.org/0000-0001-7710-6995)
- L Chini
- Rosa Cervone
- Giulia Brindisi (ORCID: https://orcid.org/0000-0001-5059-6082)
- Salvatore Tripodi (ORCID: https://orcid.org/0000-0003-2517-3285)
- Pasquale Comberiati (ORCID: https://orcid.org/0000-0001-5209-9733)
- Valentina Panetta (ORCID: https://orcid.org/0000-0001-6058-5045)
- Paolo Maria Matricardi (ORCID: https://orcid.org/0000-0001-5485-0324)
- Viviana Moschese (ORCID: https://orcid.org/0000-0001-7650-0632)
- Anna Maria Zicari (ORCID: https://orcid.org/0000-0002-2476-1790)
- Ifigenia Sfika (ORCID: https://orcid.org/0000-0003-2365-0498)
- Francesca Cipriani (ORCID: https://orcid.org/0000-0002-2229-5263)
- Michele Miraglia del Giudice (ORCID: https://orcid.org/0000-0002-8369-5957)
- Andrea Di Rienzo Businco
- Ekaterina Potapova (ORCID: https://orcid.org/0000-0003-4427-6335)
- Gerald Reese
- Elena Varin
- Marcella Gallucci
- Antonella Casani
- Arianna Giannetti (ORCID: https://orcid.org/0000-0001-8243-9727)
- Iride Dello Iacono
- Roberto Bernardini
Institutions
- University of Pisa (IT)
- University of Parma (IT)
- Altair Engineering (United States) (US)
- University of Campania "Luigi Vanvitelli" (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Humboldt-Universität zu Berlin (DE)
- AIAS Bologna (IT)
- Fatebenefratelli Hospital (IT)
- Azienda USL di Bologna (IT)
- Ospedale Sandro Pertini (IT)
- Policlinico Tor Vergata (IT)
- Ospedale San Giuseppe (IT)
- Sapienza University of Rome (IT)
- University of Bologna (IT)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1016/j.waojou.2024.100975
- Citations
- 2
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.77