mTOR is an essential gate in adapting the functional response of ovine trophoblast cells under stress-inducing environments
The study demonstrates that sheep trophoblast cells can adapt to adverse conditions in the early stage of placentation by balancing, in an mTOR dependent manner, nutrient recycling and transport with relevant effects for in vitro functional properties, which could potentially impact conceptus development and survival.
Authors
- Isabella Manenti (ORCID: https://orcid.org/0000-0002-7110-0960)
- Paola Toschi (ORCID: https://orcid.org/0000-0003-0963-7254)
- Silvia Miretti
- Irene Viola (ORCID: https://orcid.org/0000-0002-4268-5613)
- Mario Baratta (ORCID: https://orcid.org/0000-0003-2537-6429)
- Paolo Accornero (ORCID: https://orcid.org/0000-0001-6094-4829)
Institutions
- University of Parma (IT)
- Ospedale San Paolo (IT)
- University of Turin (IT)
Publication Details
- Journal
- Placenta
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1016/j.placenta.2024.09.011
- Citations
- 4
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Università degli Studi di Torino