Interleukin-6 Kinetics in Blood After Acute Exercise: Mechanisms and Clinical Implications

) is a multifunctional cytokine that plays a central role in regulating immune and metabolic responses to exercise.This literature review examines the kinetics of IL-6 in the blood after acute exercise sessions, highlighting the main factors that influence its release, such as the type of exercise, intensity, duration and energy supplementation.The studies reviewed indicate that long-term aerobic exercise tends to cause more significant increases in IL-6 levels compared to resistance exercise.In addition, carbohydrate ingestion during exercise can attenuate IL-6 elevation, while fasted exercise amplifies this response.The clinical implications of these findings are discussed, especially in relation to the use of exercise as a therapeutic strategy to modulate the inflammatory state in individuals with chronic conditions.The review concludes that IL-6 is an essential mediator of adaptations to exercise and suggests directions for future research in the area.