Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Authors

Christopher John Weir (ORCID: https://orcid.org/0000-0002-6494-4903)
Giles E. Hardingham (ORCID: https://orcid.org/0000-0002-7629-5314)
Jeremy Chataway (ORCID: https://orcid.org/0000-0001-7286-6901)
Mahesh Parmar (ORCID: https://orcid.org/0000-0003-0166-1700)
Bruce B. Virgo
Bhuvaneish Thangaraj Selvaraj (ORCID: https://orcid.org/0000-0001-7299-0910)
Charis Wong (ORCID: https://orcid.org/0000-0002-8488-037X)
Beverley Gray
Amy Stenson (ORCID: https://orcid.org/0000-0002-7838-5700)
Siddharthan Chandran (ORCID: https://orcid.org/0000-0001-6827-1593)
Shuna Colville
Neil O. Carragher (ORCID: https://orcid.org/0000-0001-5541-9747)
Robert Swingler (ORCID: https://orcid.org/0000-0002-7702-8488)
Richard Anthony Parker (ORCID: https://orcid.org/0000-0002-2658-5022)
Colin Smith (ORCID: https://orcid.org/0000-0002-4507-5132)
James R. Carpenter (ORCID: https://orcid.org/0000-0003-3890-6206)
Catriona Keerie (ORCID: https://orcid.org/0000-0001-5459-6178)
Arpan R. Mehta (ORCID: https://orcid.org/0000-0002-5715-5025)
Rachel Dakin (ORCID: https://orcid.org/0000-0002-3697-8516)
Euan MacDonald
Nigel Stallard (ORCID: https://orcid.org/0000-0001-7781-1512)
Suvankar Pal (ORCID: https://orcid.org/0000-0003-4276-639X)
Malcolm Macleod (ORCID: https://orcid.org/0000-0001-9187-9839)
Judith Newton (ORCID: https://orcid.org/0000-0002-4683-8656)
Amarachi Ihenacho
Dawn Lyle
Nicola Waters
S. Morris
Donald D. MacDonald

Institutions

Imperial College Healthcare NHS Trust (GB)
University of Dundee (GB)
Edinburgh Cancer Research (GB)
University of Warwick (GB)
MRC Clinical Trials Unit at UCL (GB)
MRC Centre for Regenerative Medicine (GB)
UK Dementia Research Institute (GB)
University College London (GB)
University of Edinburgh (GB)

Publication Details

Journal: The Lancet Neurology
Published: 2024-09-19
DOI: https://doi.org/10.1016/s1474-4422(24)00326-0
Citations: 8
Primary Topic: Amyotrophic Lateral Sclerosis Research
Type: article
Field-Weighted Citation Impact: 2.95

Funders

U.S. Department of Defense
MND Scotland
University of Edinburgh
Medical Research Council

Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Christopher John Weir, Giles E. Hardingham, Jeremy Chataway, Mahesh Parmar, Bruce B. Virgo, Bhuvaneish Thangaraj Selvaraj, Charis Wong, Beverley Gray, Amy Stenson, Siddharthan Chandran, Shuna Colville, Neil O. Carragher, Robert Swingler, Richard Anthony Parker, Colin Smith, James R. Carpenter, Catriona Keerie, Arpan R. Mehta, Rachel Dakin, Euan MacDonald, Nigel Stallard, Suvankar Pal, Malcolm Macleod, Judith Newton, Amarachi Ihenacho, Dawn Lyle, Nicola Waters, S. Morris, Donald D. MacDonald

September 19, 2024article en

8 citations

Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Authors

Institutions

Publication Details

Funders

Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Abstract

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