CPEB2-activated Prdm16 translation promotes brown adipocyte function and prevents obesity
In addition to Ucp1L, activation of Prdm16 translation by CPEB2 is critical for sustaining brown adipocyte function. These findings unveil a new layer of post-transcriptional regulation governed by CPEB2, fine-tuning thermogenic and metabolic activities of brown adipocytes to control body weight.
Authors
- Chi Peng (ORCID: https://orcid.org/0000-0002-2527-8397)
- Huifeng Chen (ORCID: https://orcid.org/0000-0002-5381-1793)
- Pei-Chih King
- Yi‐Shuian Huang (ORCID: https://orcid.org/0000-0001-9000-7748)
- Wen-Hsin Lu
Institutions
- Institute of Biomedical Sciences, Academia Sinica (TW)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1016/j.molmet.2024.102034
- Citations
- 4
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Academia Sinica
- Taipei Medical University
- National Health Research Institutes
- National Science and Technology Council