Vortioxetine reduces the development of pain‐related behaviour in a knee osteoarthritis model in rats: Involvement of nerve growth factor (NGF) down‐regulation
Vortioxetine may be effective against the development of chronic pain in OA. Its antihyperalgesic effect may be mediated, at least in part, by normalization of NGF expression in the affected joint. Decrease of localized oxidative stress and of expression of pain-related mediators that contribute to central sensitization are also involved in vortioxetine's antihyperalgesic effect, in a sex-specific pattern.
Authors
- Katarina Nastić (ORCID: https://orcid.org/0009-0002-7052-7548)
- Aleksandar Jovanović (ORCID: https://orcid.org/0000-0002-1214-9318)
- Uroš Pecikoza (ORCID: https://orcid.org/0000-0002-2732-5978)
- Radica Stepanović‐Petrović
- Emilija Brdarić (ORCID: https://orcid.org/0000-0002-5980-5394)
- Ana Micov (ORCID: https://orcid.org/0000-0003-1731-4631)
- Jelena Kotur‐Stevuljević (ORCID: https://orcid.org/0000-0002-6980-3069)
- Miroslav Dinić (ORCID: https://orcid.org/0000-0001-5275-4531)
- Maja Tomić (ORCID: https://orcid.org/0000-0002-5178-7355)
- Danijela Milenković (ORCID: https://orcid.org/0000-0002-6599-4873)
- David Pavićević
Institutions
- University of Nicosia (CY)
- University of Belgrade (RS)
- University of Belgrade – Faculty of Pharmacy
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1111/bph.17342
- Citations
- 4
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Science Fund of the Republic of Serbia