Cardiovascular Disease, Brain Glucose Metabolism, and Neurocognitive Decline in People With Human Immunodeficiency Virus
We found that high ASCVD scores in a group of treated PWH were related to thalamic hypometabolism, which in turn correlated with neurocognitive decline. Our findings support the contribution of CVD to neurocognitive dysfunction. More proactive CVD management may have a role in mitigating progression of cognitive impairment. Lack of change in global brain glucose metabolism despite documented accelerated gray matter volume loss over the same period suggests that FDG PET might underestimate neuronal injury in PWH compared to structural magnetic resonance imaging.
Authors
- Avindra Nath (ORCID: https://orcid.org/0000-0003-0927-5855)
- Bryan Smith (ORCID: https://orcid.org/0000-0001-9850-5944)
- Chuen‐Yen Lau (ORCID: https://orcid.org/0000-0002-4337-8885)
- Swati Shah (ORCID: https://orcid.org/0000-0002-7333-9086)
- Alice Chien
- Erin Kelly (ORCID: https://orcid.org/0009-0004-7272-5411)
- Paul Wakim (ORCID: https://orcid.org/0000-0002-5951-0983)
- Govind Nair (ORCID: https://orcid.org/0000-0003-3725-615X)
- Elizabeth Horne (ORCID: https://orcid.org/0000-0002-3781-9285)
- Dima A. Hammoud (ORCID: https://orcid.org/0000-0001-7406-7871)
- Alan Kim (ORCID: https://orcid.org/0000-0002-5432-6386)
- Amelia L. Mitchell (ORCID: https://orcid.org/0009-0002-4778-7157)
- Cynthia McMahan (ORCID: https://orcid.org/0000-0001-9558-9812)
- Joseph Snow (ORCID: https://orcid.org/0000-0002-3015-1171)
- Anna Lyndaker (ORCID: https://orcid.org/0009-0004-8699-4129)
- Elyse Gollomp
- Cynthia Monroe (ORCID: https://orcid.org/0009-0004-5323-4609)
- Alicia Spiegel
Institutions
- National Institutes of Health (US)
- National Institute of Neurological Disorders and Stroke (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- National Institutes of Health Clinical Center (US)
- National Institute of Mental Health (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1093/ofid/ofae552
- Citations
- 2
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- National Institute of Mental Health
- National Cancer Institute
- National Institute of Neurological Disorders and Stroke
- NIH Clinical Center
- Office of AIDS Research